Allelic Complementation Between MHC Haplotypes BQ and B17ËIncreases Regression o
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چکیده
Major histocompatibility (B) complex haplotypes BQ and B17 were examined for their effect on Rous sarcoma outcome. Pedigree matings of BQB17 chickens from the second backcross generation (BC2) of Line UCD 001 (BQBQ) mated to Line UCD 003 (B17B17) produced progeny with genotypes BQBQ, BQB17, and B17B17. Sixweek-old chickens were injected with subgroup A Rous sarcoma virus (RSV). The tumors were scored for size at 2, 3, 4, 6, 8, and 10 weeks postinoculation. A tumor profile index (TPI) was assigned to each bird based on the six tumor scores. Two experiments with two trials each were conducted. In Experiment 1, chickens (n = 84) were inoculated with 30 pock-forming units (pfu) RSV. There was no significant B genotype effect on tumor growth over (
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